ChemInform Abstract: Concise Copper‐Catalyzed Synthesis of Tricyclic Biaryl Ether‐Linked Aza‐Heterocyclic Ring Systems.

Abstract

A new method for the synthesis of tricyclic biaryl ether-linked ring systems incorporating seven-, eight-, and nine-membered ring amines is presented. In the presence of catalytic quantities of copper(I), readily accessible acyclic precursors undergo an intramolecular carbon–oxygen bond-forming reaction facilitated by a “templating” chelating nitrogen atom. The methodology displays a broad substrate scope, is practical, and generates rare and biologically interesting tricyclic heteroaromatic products that are difficult to access by other means.