ChemInform Abstract: Chiral Phosphine—Phosphite Ligands in the Enantioselective 1,4‐Addition of Grignard Reagents to α,β‐Unsaturated Carbonyl Compounds.

Abstract

AbstractCopper‐catalyzed asymmetric 1,4‐addition of Grignard reagents towards cyclic ketones proceeds efficiently in the presence of novel chiral phosphine—phosphite ligands (I) to give the adducts (IV) and (VI) in up to 93% optical purity.