Abstract
α-Arylethanamines were investigated as organocatalysts for the α-amination of branched aldehydes with azodicarboxylates. Optimization identified (R)-1-(1-naphthyl)ethanamine (1g) as an effective and enantioselective organocatalyst; multifunctional chiral quaternary amino aldehydes were successfully obtained in excellent yields (up to 99 %) and with excellent enantioselectivities (up to 98 % ee).
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