ChemInform Abstract: Catalytic Sulfur‐Enabled Dehydrobicyclization of 1,6‐Enynes Toward Arylated Indeno[1,2‐c]thiophenes.

Abstract

A new copper-catalyzed sulfur-enabled dehydrobicyclization of 1,6-enynes using potassium sulfide as a sulfurating reagent has been established, providing a straightforward access toward arylated indeno[1,2-c]thiophenes with moderate to good yields. This sulfur incorporation pathway involves Michael addition, 5-exo-dig/5-endo-trig bicyclization and dehydrogenation sequence, resulting in continuous multiple bond-forming events including C–S and C–C bonds to rapidly construct functional organic molecules.