ChemInform Abstract: Broensted Base‐Catalyzed Three‐Component Coupling Reaction of α‐Ketoesters, Imines, and Diethyl Phosphite Utilizing [1,2]‐Phospha‐Brook Rearrangement.

Abstract

AbstractThe title reaction involves the generation of ester enolates via the umpolung process, i.e., the chemoselective addition of diethyl phosphite to α‐ketoesters followed by [1,2]‐phospha‐Brook rearrangement, and the trapping of the resulting enolates by imines preferentially over α‐ketoesters and protons.