ChemInform Abstract: Aza‐[1,2]‐Wittig Rearrangements of N‐Benzyl Glycine Methyl Esters. A New Approach to the Synthesis of N‐Aryl Phenylalanine Derivatives.

Renata K Everett,John P Wolfe

doi:10.1002/chin.201538080

ChemInform Abstract: Aza‐[1,2]‐Wittig Rearrangements of N‐Benzyl Glycine Methyl Esters. A New Approach to the Synthesis of N‐Aryl Phenylalanine Derivatives.

Renata K Everett, John P Wolfe

https://doi.org/10.1002/chin.201538080

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Journal: ChemInform

Publication Date: Sep 1, 2015

Affiliation: Ann Arbor Center for Independent Living

#Glycine Methyl Ester #Wittig Rearrangement + Show 8 more

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Abstract

Treatment of N-(arylmethyl)-N-aryl glycine methyl ester derivatives with Bu2BOTf and iPr2NEt effects an aza-[1,2]-Wittig rearrangement that provides N-aryl phenylalanine methyl esters in good yields. Analogous substrates bearing N-carbonyl groups are converted to 1,4,2-oxazaborole derivatives under similar conditions.

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