Abstract
An organocatalytic Michael addition of protected 2-amino-1-nitroethanes to α,β-unsaturated aldehydes followed by treatment with TFA afforded 4-substituted 3-nitro-1,2,3,4-tetrahydropyridines with good diastereoselectivity and excellent enantioselectivity. Good yields were observed in the case of β-aryl-substituted α,β-unsaturated aldehydes as the substrates, while moderate yields were obtained when β-alkyl-substituted α,β-unsaturated aldehydes were used.
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