ChemInform Abstract: An Original One-Pot Synthesis of 5-(4-Pyridyl)-benzo(c)-2,7- naphthyridine as Key Intermediate in the Synthesis of Amphimedine by Metalation Connected with Cross-Coupling Reaction.

Abstract

Abstract A short new route to 4,5-disubstituted-benzo[c]-2,7-naphthyridines has been developed. The strategy involves directed ortho metalation of pyridines following by an halogen dance reaction and biaryl cross-coupling as key steps. A concise and efficient one-pot synthesis of 4-chloro-5-(4-pyridyl)-benzo[c]-2,7-naphthyridine, as a key intermediate in the synthesis of amphimedine is described.