ChemInform Abstract: An Efficient and Facile One‐Pot Synthesis of Propargylamines by Three‐Component Coupling of Aldehydes, Amines, and Alkynes via C—H Activation Catalyzed by NiCl2.

Abstract

NiCl2 was found to be a highly efficient and effective catalyst for the one-pot three-component (A3) coupling of aldehydes, amines, and alkynes to produce propargylamines in nearly quantitative yields. Structurally divergent aldehydes, amines, and alkynes were converted into the corresponding propargylamines. No co-catalyst or activator is needed and water is the only byproduct of this novel protocol.