ChemInform Abstract: A Recyclable Organocascade Reaction System: Stereoselective Precipitation of Optically Active cis‐δ‐Lactols with Quaternary Stereocenters During the Michael—Hemiacetalization Reaction.

Abstract

AbstractCascade Michael addition—hemiacetalization reaction of β‐nitroethanols and α,β‐unsaturated aldehydes is smoothly catalyzed by a prolinol‐derived organocatalyst to give cis‐substituted tetrahydropyranols (III), (V) and (IX) in excellent enantioselectivity, although diastereoselectivity is only moderate.