Abstract
By a one-pot tandem Ugi multicomponent reaction (MCR)/click reaction sequence not requiring protecting groups, 1H-1,2,3-triazole-modified Ugi-reaction products 6a–6n (Scheme 1 and Table 2), 7a–7b (Table 4), and 8 (Scheme 2) were synthesized successfully. i.e., terminal, side-chain, or both side-chain and terminal triazole-modified Ugi-reaction products as potential amino acid units for peptide syntheses. Different catalyst systems for the click reaction were examined to find the optimal reaction conditions (Table 1, Scheme 1). Finally, an efficient Ugi MCR+Ugi MCR/click reaction strategy was elaborated in which two Ugi-reaction products were coupled by a click reaction, thus incorporating the triazole fragment into the center of peptidomimetics (Scheme 3). Thus, the Ugi MCR/click reaction sequence is a convenient and simple approach to different 1H-1,2,3-triazole-modified amino acid derivatives and peptidomimetics.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
