Abstract
Abstract Some bisphosphonic acids containing basic side chain sub-stituents are compounds of pharmaceutical interest which are undergoing clinical investigation as agents for the treatment of various bone diseases. 3-Amino-propane-l-hydroxy-1,l-bisphosphonic acid (pamidronic acid, APD) is a well known member of this series (1). When APD was subjected to trimethylsilylation and subsequent distillation at low pressure, a novel rearrangement was observed:
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