Abstract
In a novel approach starting from O-trimethylsilyl protected or unprotected cyanohydrins and oxalyl chloride or bromide, a series of unkown 6-substituted 3,5-dihalo-2H,1,4-oxazin-2-ones were prepared. The method was shown to be efficient for various types of cyanohydrins; however cyclization was not obtained with cyanohydrins containing bulky substituents, electron-rich aryl or heteroaryl groups. A mechanism is proposed.
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