Abstract
1,3-Dipolar cycloaddition of α,β-unsaturated ketones bearing 1,2,3-triazole moiety with nitrile oxides and sydnones obtained a series of novel 3,4,5-trisubstituted isoxazolines (5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h) and 1,3,4-trisubstituted pyrazoles (7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h) with different active pharmacophores in a single molecular scaffold. The structure of the target compounds was confirmed on the basis of IR, 1H NMR, mass spectral, elemental analysis, and X-ray crystallographic analysis.
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