Abstract
Chemiluminescence detectors have become increasingly important in the analytical world because of their inherent advantages in chromatographic detection— that is, extremely high element-selectivity and sensitivity. Benn et al. showed detailed examples for (GC-CLND) detection of nitrogen containing components in flavors and essential oils. CLND for HPLC was first described for the detection of ammonium nitrogen in waste water. The CLND was successfully interfaced for the first time to capillary SFC and studied extensively in terms of detector optimization under supercritical fluid conditions: (1) without a column for flow injection analysis, and (2) for capillary chromatography. More recently, new pharmaceutical applications are reported, where polar nitrogen containing compounds are eluted from packed column SFC with methanol modified CO 2 and detected using the CLND. SFC-CLND has opened a new dimension in analytical chemistry. Its intrinsic use in the nitrogen-specific detection mode is presented for analysis of horseradish oil and other nitrogen containing compounds. Applications with the novel simultaneous CLND/FID for capillary SFC are also discussed in the chapter.
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