Abstract
BackgroundDue to the high rate of asymptomatic infections an advanced screening assay is of prompt importance to be used for the clinical diagnosis of HCV. Early detection of anti HCV is the first step in the management of chronic hepatitis and in the selection of patients needing treatments. In the current study we have first time used the advanced serological diagnostic technique i.e. Chemiluminescent Microparticle Immuno Assay (CMIA) for the detection of HCV infection in Peshawar Pakistan.MethodsA total number of 982 samples were collected among the general public belongs to the different areas of district Peshawar. The samples were centrifuged at high speed to obtain a clear supernatant serum. All the samples were run on Architect system a fully automated immuno analyzer CMIA base technology.ResultsOut of 982 blood samples analyzed in this study, 160 (15.9%) were confirmed to be positive for active HCV infection. The overall prevalence was found to be 13.4%. Gender wise prevalence was recorded to be higher in male (19.1%) than female (12.7%). The age group 21-30 years was identified as the highest risk group among the studied population.ConclusionAmong the tested samples, overall prevalence of active HCV infection was found to be 13.4% in the general population of Peshawar Pakistan. The young middle aged population of this region was at higher risk of HCV ailments compared to the other age groups.
Highlights
Due to the high rate of asymptomatic infections an advanced screening assay is of prompt importance to be used for the clinical diagnosis of Hepatitis C virus (HCV)
The current study we have focused on, the Chemiluminescent Microparticle Immuno Assay (CMIA), an advanced serological diagnostic technique, provides a rapid, cost-effective and reliable way to detect HCV, and is the method that was implemented for the diagnosis of hepatitis infection
A total of 982 blood samples were collected from the district Peshawar Pakistan and were screened for anti HCV
Summary
Due to the high rate of asymptomatic infections an advanced screening assay is of prompt importance to be used for the clinical diagnosis of HCV. Detection of anti HCV is the first step in the management of chronic hepatitis and in the selection of patients needing treatments. At early stages the infection is asymptomatic but once established, it can progress to advanced liver diseases such as liver fibrosis and cirrhosis. These liver diseases can further lead to other complications such as liver failure and liver cancer [1]. About 70-80% acute HCV infections become chronic that leads to the development of cirrhosis in 20% of cases while the same
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