Abstract
A new chemiluminescence method is described for the determination of 6-mercaptopurine. In the presence of tris(2,2’-bipyridine)ruthenium(II), 6-mercaptopurine (6MP) and hydrogen peroxide, upon the addition of hydroxide ion, resulted in intense light emission. The emission intensity is greatly enhanced by the presence of Tween-20. The linear range and detection limit of 6MP are 1.4×10-5− 1.4×10-g g/ml and 3×l0-10 g/ml, respectively. The method was evaluated by carrying out an interference study with common excipients and other coexisting compounds, by a recovery study and by the analysis of commercial formulation. A satisfactory result was obtained.
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