Abstract
It has been found that sodium hypochlorite enhanced the chemiluminescence (CL) of the CdTe nanocrystal (NC)-hydrogen peroxide system and that estrogens inhibited these CL signals in alkaline solution. CL spectra were used to investigate the mechanism of the CL enhancement. On the basis of the inhibition, a flow-injection CL method has been established for determination of three natural estrogens.
Highlights
Estrogens are necessary for ovarian differentiation during critical developmental windows in most vertebrates and promote the growth and differentiation of the adult female reproductive system [1]
Estrogens have been detected with some analytical procedures, including high-performance liquid chromatography [4,5,6,7,8,9], UV derivative spectrophotometric method [10], gas chromatography (GC)-mass spectrometry (MS) analytical method [11], and capillary electrophoresis [12]
The results indicated that the CL emission intensity of CdTe-hydrogen peroxide-sodium hypochlorite system could be inhibited by estrogens
Summary
Estrogens are necessary for ovarian differentiation during critical developmental windows in most vertebrates and promote the growth and differentiation of the adult female reproductive system [1]. Natural and synthetic estrogens have been characterized by the largest endocrine disrupting potential, as confirmed by both in vitro and in vivo studies [2]. The relation between estrogens and several human health problems has been previously reported, such as prostate and breast cancer, perturbation of human reproduction, and endocrine disruption on humans and wildlife [3]. Estradiol, and estriol are three main natural estrogenic hormones existing in the human body. Semiconductor nanocrystals have been widely used as fluorescence biological probes [13], donors or acceptors of fluorescence resonance energy transfer [14], and in bioimaging [15]. We found that sodium hypochlorite could enhance the CL of the CdTe NCs-hydrogen peroxide system. The results indicated that the CL emission intensity of CdTe-hydrogen peroxide-sodium hypochlorite system could be inhibited by estrogens. The development of a CL system for determination of estrone, estradiol, and estriol was established, and the mechanism was discussed
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