Abstract
Chemically induced breast tumours and the mammary tumour agent.
Highlights
Breast tumours of C3H high- and C57 low-breast-cancer strain male mice induced by combined application of oestrone and methylcholanthrene, of C3H males following treatment with oestrone, and of C57 females after treatment with methylcholanthrene were investigated for the presence of the mammary tumour agent
Four breast tumours induced in IF low-breast-cancer strain females with methylcholanthrene and one breast tumour induced in a C3H male with oestrone and methylcholanthrene were tested for the presence of the mammary tumour agent
Biological tests for the presence of the mammary tumour agent in breast cancer induced in high- and low-breast-cancer strain mice by administration of methylcholanthrene alone, oestrone alone, or combined treatment have revealed a difference between induced breast tumours according to the strain in which they originated
Summary
Breast tumours of C3H high- and C57 low-breast-cancer strain male mice induced by combined application of oestrone and methylcholanthrene, of C3H males following treatment with oestrone, and of C57 females after treatment with methylcholanthrene were investigated for the presence of the mammary tumour agent. Breast tumours induced in IF low-breast-cancer strain mice with methylcholanthrene (Orr, 1946) were examined. Breast tumour tissue desiccated and stored for periods of time varying from 1 week to 7 months was used. The tumour tissue, immediately before use, was resuspended in distilled water in a proportion of 1:10 and injected subcutaneously every other day into 4-6 weeks old susceptible C57 x RIII hybrid female mice. All females were forcibly bred by removing the first three litters and allowed to breed in a normal way.
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