Abstract
Eukaryotes organize their DNA in the form of chromatin. This complex of DNA and packaging proteins, the histones, ensures that all genomic information fits into the limited space of the cell nucleus. In addition to compacting DNA, chromatin itself regulates the activity of encoded genes. This regulatory process involves many posttranslational modifications of histone proteins and deciphering the complex crosstalk between histone modifications and gene activity represents a central challenge for biomedical science. This task has often been supported by sophisticated chemical tools, which were crucial for many important discoveries in this field. This review provides an overview of chemical tools for chromatin research, with emphasis on classical and current examples of their applications.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
