Abstract

AbstractCapuramycin is an important lead nucleoside antibiotic for the development of new therapeutic agents against the multidrug‐resistant Mycobacterium tuberculosis infections. Due to the poor accessibilities, the heterogeneous issues and difficulties in the modification of capuramycin at the specific positions, in‐depth studies on the structure‐activity relationships (SAR) of capuramycin are hampered. Chemical synthesis is a reliable and effective method to provide capuramycin and its analogues. Thus far, only four different synthetic routes toward capuramycin have been reported. Herein, we provide a comprehensive review on the chemical synthesis of capuramycin.

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