Abstract
α-Methyl glutamic acid (L-L)-, (L-D)-, (D-L)-, and (D-D)-γ-dimers were synthesized from L- and D-glutamic acids, and the obtained dimers were subjected to polycondensation with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 1-hydroxybenzotriazole hydrate as condensation reagents. Poly-γ-glutamic acid (γ-PGA) methyl ester with the number-average molecular weights of 5000∼20,000 were obtained by polycondensation in N,N-dimethylformamide in 44∼91% yields. The polycondensation of (L-L)- and (D-D)-dimers afforded the polymers with much larger |[α]D| compared with the corresponding dimers. The polymer could be transformed into γ-PGA by alkaline hydrolysis or transesterification into α-benzyl ester followed by hydrogenation. © 2001 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 39: 732–741, 2001
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