Abstract
A new type of non-ionic DNA analogues bearing hydroxymethylphosphonate internucleotidic linkages (HMP-DNA) were synthesized in good yields. A dimer having the hydroxymethylphosphonate linkage was synthesized from the corresponding H-phosphonate via a trimethylsilyl phosphite intermediate. This method was applied to the solid-phase synthesis of a decathymidylate having hydroxymethylphosphonate internucleotidic linkages.
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