Abstract
The chemical synthesis of 3-deoxy-1α-hydroxyvitamin D 3 from cholesterol is described. This steroid is a highly important analog of the hormonally active form of vitamin D, 1α, 25-dihydroxyvitamin D 3; it is the only analog presently available for structure-function studies which lacks the 3β-hydroxyl but retains the key 1α-hydroxyl of 1α, 25-dihydroxyvitamin D 3. The new steroid is highly biologically active; it stimulated intestinal calcium absorption significantly more rapidly than vitamin D 3 and as rapidly as 1α, 25-dihydroxyvitamin D 3.
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