Chemical Studies on Tuberactinomycin. XVII. Synthesis of threo-γ-Hydroxy-l-β-lysine, Constituent Amino Acid of Tuberactinomycin A and N

Abstract

Abstract threo-γ-Hydroxy-l-β-lysine which is a constituent amino acid of antibiotics tuberactinomycin A and N, was synthesized from threo-β-hydroxy-l-ornithine derivative by the Arndt-Eistert reaction. The synthetic amino acid was identical with the natural sample in all respects. Furthermore, a route was established to prepare a protected γ-hydroxy-β-lysine derivative useful for the peptide synthesis.