Abstract
CHEMICAL STRUCTURE IN RELATION TO VITAMIN E FUNCTION
Highlights
Olcott reported that etherification destroyed the activity of vitamin E concentrates [16]. In harmony with this we have found that the methyl ether of dl-a-tocopherol is devoid of biological activity in doses as high as 200 mg
The vitamin E activity in the rat fertility test has been measured for eight compounds of different types which have previously been reported to possess activity
All these compounds gave entirely negative results. a-Tocopheroxide possessed activity, while the methyl ether of oc-tocopherol and ar-tocopherylquinone had no biological activity in the rat fertility test
Summary
The minimum fertility dose of active compounds was calculated as suggested by Mason and Harris [6] by the procedure of Reed and Muench [7] for estimation of the 50 per cent response level. Trials with PossibleAntagonists of a-Tocopherol-These trials were made by evaluating the effect of the test compound on a rat prepared for vitamin E assay to which had been administered 1.0 to 1.5 mg. Of dl-cu-tocopherol, a dose which was slightly greater than the mean fertility dose Under these circumstances the rats should show a maximum sensitivity to compounds which might act as metabolic antagonists to vitamin E.
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