Chemical Recognition in Biology

Abstract

A. Recognition of Ligands - Enzymic Catalysis.- 1. What Everyone Wanted to Know About Tight Binding and Enzyme Catalysis, but Never Thought of Asking.- 2. The Cytochromes c: Paradigms for Chemical Recognition.- 3. Recognition of Ligands by Haem Proteins.- 4. Influences of Solvent Water on the Transition State Affinity of Enzymes, Protein Folding, and the Composition of the Genetic Code.- 5. Suicide Substrates: Mechanism-Based Inactivators of Specific Target Enzymes.- 6. Recognition: the Kinetic Concepts.- 7. Coupled Oscillator Theory of Enzyme Action.- 8. Stereochemical Aspects of Chain Lengthening and Cyclization Processes in Terpenoid Biosynthesis.- B. Enzyme Regulation.- 1. Three Multifunctional Protein Kinase Systems in Transmembrane Control.- 2. Effect of Catabolite Repression on Chemotaxis in Salmonella typhimurium.- 3. Subunit Interaction of Adenylylated Glutamine Synthetase.- 4. Dynamic Compartmentation.- 5. The Genes for and Regulation of the Enzyme Activities of two Multifunctional Proteins Required for the De Novo Pathway for UMP Biosynthesis in Mammals.- 6. Regulation of Muscle Contraction by Ca Ion.- 7. Why is Phosphate so Useful?.- 8. ppGpp, a Signal Molecule.- 9. Gramicidin S-Synthetase: On the Structure of a Polyenzyme Template in Polypeptide Synthesis.- 10. A Molecular Approach to Immunity and Pathogenicity in an Insect-Bacterial System.- C. Nucleic Acid - Protein Interactions Mutagenesis.- 1. Structure of the Gene 5 DNA Binding Protein from Bacteriophage fd and its DNA Binding Cleft.- 2. Recognition of Nucleic Acids and Chemically-Damaged DNA by Peptides and Proteins.- 3. Specific Interaction of Base-Specific Nucleases with Nucleosides and Nucleotides.- 4. Structural and Dynamic Aspects of Recognition Between tRNAs and Aminoacyl-tRNA Synthetases.- 5. Recognition of Promoter Sequences by RNA Polymerases from Different Sources.- 6. DNA as a Target for a Protein Antibiotic: Molecular Basis of Action.- 7. Site-Specific Mutagenesis in the Analysis of a Viral Replicon.- D. Protein Biosynthesis.- 1. Molecular Mechanism of Protein Biosynthesis and an Approach to the Mechanism of Energy Transduction.- 2. On Codon - Anticodon Interactions.- 3. Fluorescent tRNA Derivatives and Ribosome Recognition.- 4. Structure and Evolution of Ribosomes.- E. Philosophical Reflexions.- 1. Molecular Biology, Culture, and Society.- 2. Personal Recollections of Fritz Lipmann During the Early Years of Coenzyme A Research.