Abstract
The synthesis of the formally monofunctional bis(platinum) complex [{Pt(NH} 3) 3μ-H 2N(CH 2) 4NH 2-{ trans-PtCl(NH 3) 2}] 3+ (1,0/t) is reported. The interactions of this species and the formally bifunctional bis(platinum) complex [{ trans-PtCl(NH 3) 2} 2H 2N(CH 2) NH 2]Cl 2 (1,1/t,t) with DNA were investigated. Comparison was made with the monomeric [PtCl(dien)]Cl, (Pt(DIEN)), and cis-[PtCl 2(NH 3) 2], ( cis-DDP). The initial rates of reaction with small self-complementary oligonucleotides 5′-ATATATN 4ATATAT-3′ (N 4 = GCGC and N 4 = GGCC) were calculated. For all compounds, the GGCC oligonucleotide reacted faster than the GCGC counterpart. The order of reactivity of the platinum compounds for the GCGC oligonucleotide was 1,1/t,t > 1,0/t > Pt(DIEN) > cis-DDP. The reaction of 1,0/t and 1,1/t,t with poly(dGdC)·poly(dGdC) was also investigated using circular dichroism (CD) spectroscopy where both compounds were shown to induce a B → Z conformational change.
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