Abstract
AbstractThe dissolution of naproxen from inert matrices (monoliths) has been studied; the matrices were obtained by direct compression using polymeric materials as support. The influence of the chemical form employed (acid or salt) and of the affinity of the drug to the supporting material on the release process are discussed. Release experiments were carried out in the columnar cell of a laminar flux apparatus. They showed that the solubility of the chemical form employed is more important for the dissolution of naproxen from monoliths than the drug's affinity to the supporting material.
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