Abstract
A reagent that traps nitric oxide for monitoring, quantitative determination, and imaging by electron spin resonance (ESR) spectrometry has been devised by chemists at the Universities of Dusseldorf and Essen, Germany, and the National Research Council of Canada, Ottawa [ Angew. Chem. , 104 , 915 (1992)]. With further development, this achievement seems likely to have an impact on both environmental chemistry and medical research. In addition to its environmental role as an air pollutant, nitric oxide functions in living systems to transmit nerve signals, prevent blood clots, release insulin, kill bacteria, and relax blood vessels to control blood pressure. Just last month, researchers from Johns Hopkins University School of Medicine reported on work establishing nitric oxide as a physiologic mediator of penile erection [ Science , 257 ,401 (1992)]. However, derangements of nitric oxide biosynthesis may cause nerve death after injury or in such degenerative ailments as Alzheimer's, Huntington's, or Parkin...
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