Abstract
Skin as an important site of drug application for both local and systemic effects. However in skin, the stratum corneum is the main barrier for drug penetration. Penetration enhancement technology is a challenging development that would increase the number of drugs availablefor transdermal administration. The permeation of drug through skin can be enhanced by both chemical penetration enhancement and physical methods. In this review, we have discussed the chemical penetration enhancement technology for transdermal drug delivery as well as the probable mechanisms of action.
Highlights
The transdermal route ranks with oral treatment as the most successful innovative research area in drug delivey, with around 40% of the drug delivery candidate products under clinical evaluation related to transdermal or dermal system
The method employed for modifying the barrier properties of the stratum corneum to enhance drug penetration and absorption through skin may be classified into the following categories4: 1. Chemical enhancement 2
Skin permeation enhancement technology is a rapidly developing field which would significantly increase the number of drugs suitable for transdermal drug delivery, with the result that skin will become one of major routes of drug administration in the decade
Summary
The transdermal route ranks with oral treatment as the most successful innovative research area in drug delivey, with around 40% of the drug delivery candidate products under clinical evaluation related to transdermal or dermal system. The method employed for modifying the barrier properties of the stratum corneum to enhance drug penetration and absorption through skin may be classified into the following categories4: 1. Penetration enhancers reversibly reduce the barrier resistance of the stratum corneum without damaging viable cells[13,14]. The fatty acid enhancers increased the fluidity of the lipid protein portion of the stratum corneum.
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