Abstract
We present an overall scheme for chemical mutagen risk assessment, which leads naturally to consideration of Haber's rule, a classical concept of toxicology. A rationale is given for considering compartmental models based on mammalian anatomy and physiology as the most reasonable and practical conceptual framework for risk assessment. Haber's rule is extended to the area of chemical dosimetry, defined in terms of our compartmental models. Then it is proved that Haber's rule holds for any system of linear ordinary differential equations with constant coefficients which is physically realizable. Finally, we comment on non-linearities and on the Blum-Druckey model for time-to-occurrence of tumors.
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