Abstract
Pradimicin A (PRM-A) is an actinomycete-derived antibiotic that shows antifungal activity through binding to d-mannose (Man)-containing glycans of fungi. Despite its unique mode of antifungal action, therapeutic application of PRM-A has been severely limited by the aggregate-forming property. In this study, we demonstrated that C4′-N-formyl PRM-A and the dexylosylated derivative of C4′-N-acetyl PRM-A showed significant Man-binding and antifungal activities without any aggregation or precipitation. The presented results provide a promising modification strategy for exploring the therapeutic application of PRM-A.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
