Abstract
Cellulose membranes markedly promote the complement activation during haemodialysis treatment. The polysaccharide structure with the special arrangement of hydroxyl groups at the anhydroglucose unit can be postulated as a trigger for activation. Therefore the hydroxyl groups localised at the surface of the membrane were masked by heterogeneous derivatisation and grafting with reactive polymers, especially by introduction of polar and/or ionic groups bound covalently on the membrane surface. The chemical treatment, the resulting physico-chemical properties and the blood compatibility of the modified surface are discussed. Membranes modified by the introduction of sulphate, sulphonate and carboxylic groups demonstrated a clear decrease in complement activation (C3a des Arg) in comparison to pure cellulose.
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