Abstract
Long-term efforts to decode plant cellulose biosynthesis via molecular genetics and biochemical strategies are being enhanced by the ever-expanding scale of omics technologies. An alternative approach to consider are the prospects for inducing change in plant metabolism using exogenously supplied chemical ligands. Cellulose biosynthesis inhibitors (CBIs) have been identified among known herbicides, during diverse combinatorial chemical libraries screens, and natural chemical screens from microbial agents. In this review, we summarize the current knowledge of the inhibitory effects of CBIs and further group them by how they influence fluorescently tagged cellulose synthase A proteins. Additional attention is paid to the continuing development of the CBI toolbox to explore the cell biology and genetic mechanisms underpinning effector molecule activity.
Highlights
With the advent of next-generation sequencing it is feasible to map single base pair mutations using a small number of homozygous individuals within a mapping population
The use of cell biology to examine cellulose biosynthesis inhibitors (CBIs) has been a valuable intermediary that allows the researcher to explore the mechanism by which cellulose synthase A (CESA) responds to the drug, and secondly learn more about CESA behavior in living cells
The CESA arrays were disorganized compared to control cells, but instead of clearing CESA from the plasma membrane, morlin treated cells displayed reduced CESA velocity that was independent of MTs
Summary
Plant Physiology, Department of Horticulture, University of Kentucky, Lexington, KY, USA. Reviewed by: Stephanie Robert, Swedish University of Agricultural Sciences/Umeå Plant Science Centre, Sweden Alison Roberts, University of Rhode Island, USA. Long-term efforts to decode plant cellulose biosynthesis via molecular genetics and biochemical strategies are being enhanced by the ever-expanding scale of omics technologies. Cellulose biosynthesis inhibitors (CBIs) have been identified among known herbicides, during diverse combinatorial chemical libraries screens, and natural chemical screens from microbial agents. We summarize the current knowledge of the inhibitory effects of CBIs and further group them by how they influence fluorescently tagged cellulose synthase A proteins. Additional attention is paid to the continuing development of the CBI toolbox to explore the cell biology and genetic mechanisms underpinning effector molecule activity
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