Abstract
The binding of 63Ni to low-molecular-weight constituents of rat plasma, kidney cytosol and urine has been investigated in vivo and in vitro. Comparative tissue distribution and excretion of 63Ni in rats after administration of 63NiCl2 through various routes revealed that among rat organs, the kidney showed the highest affinity for 63Ni and that radio-nickel was excreted easily into the urine by way of the kidney. Sephadex G-25 and G-200 gel chromatographies of plasma, kidney cytosol and urine after iv or po administration of 63NiCl2 demonstrated that a major component of nickel metabolite in the rat urine may originate from one of three Ni-complexes with low molecular weight in the plasma and kidney cytosol. The behaviors of Ni-complex on thin layer chromatography and Sephadex G-25 gel chromatography suggested that one of the metabolites in the rat urine after iv or po administration of 63NiCl2 existed as a complex of nickel with a picrate-forming substance resembling creatine-related substances.
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