Abstract
Cyclocarya paliurus is an edible and medicinal plant containing various bioactive components with significant health benefits. A combinative method using high-performance liquid chromatography (HPLC) fingerprint and quantitative analysis was developed and successfully applied for characterization and quality evaluation of C. paliurus leaves collected from 18 geographical locations of China. For the fingerprint analysis, 21 common peaks were observed among the 18 samples, and these peaks were identified by high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC–Q–TOF–MS), while a simultaneous quantification of 16 markers was conducted to interpret the variations of contents of these bioactive compounds among the C. paliurus leaves from different geographical locations. Quantification results showed that the contents of these sixteen investigated compounds varied greatly among the leaves from different locations. The developed new method would be a valuable reference for further study and development of this bioactive plant.
Highlights
Cyclocarya paliurus is a monotypic genus belonging to the Juglandaceae family, which is mainly distributed in the highlands of subtropical regions in China [1]
The aim of this study was to provide comprehensive understandings of chemical profile, quantitative analysis and similarity evaluation of C. paliurus leaves from different geographic locations, which could be a valuable reference for further study and development of this plant
In order to extract the bioactive substances sufficiently and obtain as much fingerprint information as possible, the extraction methods, extraction solvents and extraction time were optimized by using a univariate approach
Summary
Cyclocarya paliurus is a monotypic genus belonging to the Juglandaceae family, which is mainly distributed in the highlands of subtropical regions in China [1]. A great deal of modern pharmacological studies have demonstrated that leaves of C. paliurus possess biological functions, including enhanced antihypertensive activity, hypoglycemic activity, hypolipidemic activity, improving mental efficiency, anticancer, anti-HIV-1, antibacterial and antioxidant activity [4,5,6,7,8,9,10,11,12,13]. These potential health benefits are attributed to the bioactive compounds in the leaves of C. paliurus. It is noteworthy that several distinctive triterpene compounds named cyclocarioside I, cyclocarioside II, cyclocarioside III, Molecules 2017, 22, 1927; doi:10.3390/molecules22111927 www.mdpi.com/journal/molecules
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