Abstract
Analyses of total 3-hydroxyproline and 4-hydroxyproline in tissue samples can be used to estimate the quantity of two kinds of collagen: that of basement-membrane and that of the several interstitial Types. Applied to an experimental model for obstructive nephropathy in the rabbit, such data show that the large increase in collagen in the renal cortex (at the 32nd day following unilateral ureteral ligation) is primarily of interstitial type. However there is also an appreciable increase in basement membrane collagen. Both findings are in agreement with the qualitative impression from electronmicrographs. The chemical method offers an approach to quantitation of these two kinds of collagen (basement membrane and interestitial) in normal and diseased tissues.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
