Abstract
This experiment exposes undergraduate students to the field of supramolecular chemistry by means of an inclusion equilibrium between cyclic oligosaccharides (β- or γ-cyclodextrin) and surfactants (sodium octanoate or sodium decanoate) as studied by 1H NMR. This technique is especially suitable in molecules that neither absorb nor emit optical radiation when excited. The induced chemical shifts that occur in both guest and host protons upon inclusion give valuable structural information about the stoichiometry and geometry of the complex, and permit the estimation of the binding constants through a nonlinear least-squares analysis of selected protons of the system. The effect of the host cavity size and hydrophobicity of the surfactant on the complex stability is also discussed.
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