Abstract
ABSTRACTTwo new secondary metabolites, kongiilines A and B (1, 7), and two asperphenamate derivatives, asperphenamates B and C (5–6), together with 16 known compounds (2–4, 8–20), were isolated from Tibetan Plateau fungi Penicillium kongii and Penicillium brasilianum. This is the first report on asperphenamates B and C as naturally occurring compounds, and that aspterric acid is isolated from P. brasilianum for the first time. Their structures were elucidated by different spectroscopic techniques including high-resolution electrospray ionisation mass spectrum, 1D nuclear magnetic resonance (NMR), and 2D NMR as well as electronic circular dichroism. Compounds 4, 5, and 10 exhibited cytotoxicity activities against human colon carcinoma HCT116 cell line with IC50 values of 88.16, 77.68, and 36.92 μM, respectively. Fungi from Tibetan Plateau represent important and rich resources for the investigation of new chemicals.
Highlights
The genus Penicillium is a major contributor to the production of bioactive molecules
Many mycotoxins causing human and animal diseases were produced in some species of Penicillium, such as citreoviridin, citrinin (CIT), ochratoxin A (OTA), patulin (PAT), penitrem A, and penicillic acid (PA) (Lee & Ryu 2015; Oh et al 2017)
Penicillium strain XZ135R was identified as P. kongii, and XZ94 was identified as P. brasilianum according to beta-tubulin gene (BenA, GenBank No MF036174) and calmodulin gene (CaM, GenBank No MF039288)
Summary
The genus Penicillium is a major contributor to the production of bioactive molecules. In the past few years, a series of bioactive molecules or new skeletons has been isolated from Tibetan. Plateau origin fungi, such as phaeolschidins, with antioxidant activity, from Phaeolus schweinitzii (Abbas et al 2013; Han et al 2013), new skeletons, sterhirsutins, with cytotoxic and immunosuppressant activities from Stereum hirsutum (Qi et al 2014, 2015), anthraquinone derivatives, with antitumour activities, from an Alternaria species (Chen et al 2014), sarcoviolins, with antioxidative and α-glucosidase inhibitory activities, from Sarcodon leucopus (Ma et al 2014a), Gloeophyllins A–J, as cytotoxic ergosteroids, from Gloeophyllum abietinum (Han et al 2015). We described the compound isolation, structural elucidation, and bioactivity evaluations for new compounds
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
