Chemical Differentiation of Nervous and Hormonal Pancreatic Secretion

Abstract

We have previously presented data to show that the secretion of pancreatic juice is continuous1 and can be clearly demonstrated in dogs if the use of ether anesthesia is avoided. We suggested then that a continuous phase of secretion is produced by means other than secretin. We are now presenting observations concerning the mechanism of secretion and the composition of pancreatic juice produced by various means. Our data confirm the observations of J. Mellanby,2 who came to conclusions very similar to ours. As new observations we offer those on spontaneous secretion, on the uncomplicated action of pilocarpin, together with more extensive analytical data including comparison with blood.To obtain juice under conditions of complete exclusion of secretin action, the entire small intestine was removed under amytal or avertin anesthesia after tying off the pylorus. This was accompanied by loss of blood (in the intestine) and considerable shock. In some cases no flow was found, while in others a slow steady secr...