Abstract
m-Chlorophenylpiperazine, a serotonin receptor agonist, produced dose-related decrease of TSH plasma levels in the rat. This effect was prevented by a pretreatment with metergoline, a serotonin receptor blocker. Chemical destruction of central serotonin pathways, induced by intraventricular injection of 5,7-dihydroxytryptamine, significantly increased the TSH-inhibiting effect of m-CPP. These findings suggest the possible development of supersensitivity of central serotonin receptors involved in the control of TSH secretion.
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