Abstract
Russula vinosa Lindbl is a wild edible mushroom that is usually used for original material of food and soup and has rich nutritional value. What are the nutritional ingredients? In order to answer this question, we investigated the chemical constituents of this wild functional food. Six new compounds (1–6), together with nine known ones (7–15), were isolated from R. vinosa. The six new compounds were named as vinosane (1), rulepidadione C (2), (24E)-3,4-seco-cucurbita-4,24-diene-26,29-dioic acid-3-methyl ester (3), (24E)-3,4-seco-cucurbita-4,24-diene-26-oic acid-3-ethyl ester (4), (24E)-3β-hydroxycucurbita-5,24-diene-26,29-dioic acid (5), and (2S,3S,4R,2′R)-2-(2′-hydroxydocosanoylamino)eicosane-1,3,4-triol (6). Their structures were determined based on spectroscopic methods including HR-ESI-MS, 1D, and 2D NMR. Moreover, a cell counting kit-8 (CCK-8 kit) was used to screen for the cytotoxicity of compounds 1–5 and 7–13 on mouse macrophage RAW 264.7 cells. The results showed that compounds 1–5 and 7–13 had no obvious cytotoxicity. In addition, the inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated mouse macrophage RAW 264.7 cells were evaluated. Compounds 1, 3, 4, 7, 12, and 13 showed moderate inhibitory activity on NO production.
Highlights
Russula vinosa Lindbl belongs to the genus of Russula, a multifunctional edible fungus, which is distributed mainly in Northwest Fujian province and Jiangxi province in China
We could see that triterpenoids and sesquiterpenoids were its main chemical constituents, which was similar to other mushrooms in this genus
Illudoid sesquiterpenes were obtained from the fruit body of R. japonica with neurite outgrowth promoting activity [8]; triterpenes and sesquiterpenes were found from R. lepida with anti-tumor activity [10]; the chemical composition was researched on R. griseocarnosa sp. nov. with antioxidant activities [22], etc
Summary
Russula vinosa Lindbl belongs to the genus of Russula, a multifunctional edible fungus, which is distributed mainly in Northwest Fujian province and Jiangxi province in China. Molecules 2019, 24, x such as anti-tumor, anti-inflammation, anti-oxidant, and antibacterial effects [4,5,6,7] Several bioactivities, such as anti-tumor, anti-inflammation, anti-oxidant, and antibacterial effects the chemical analysis of the Russula edible fungus was performed by the natural product chemistry [4,5,6,7]. The chemical analysis of the Russula edible fungus was performed by the and food chemistry scientists. The chemical constituents of several other mushrooms have been natural product chemistry and food chemistry scientists. The chemical constituents of several other investigated, such as R. japonica, R. subnigricans, R. lepida, R. cyanoxantha, etc. R. vinosa has mushrooms have been investigated, such as R. japonica, R. subnigricans, R. lepida, R. cyanoxantha, etc
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