Abstract
As a traditional medicine with potential antioxidant effects, Tenodera angustipennis egg cases (Mantidis ootheca) are a potential source of new bioactive substances. Herein, three new N-acetyldopamine derivatives, namely, (+)-tenoderin A (1a), (−)-tenoderin A (1b), and tenoderin B (2), along with thirteen known compounds (3–15), were isolated from a 70% EtOH extract of T. angustipennis egg cases. Compound 1 was isolated as a racemic mixture, and two enantiomers (1a and 1b) were successfully separated by chiral-phase preparative HPLC. The chemical structures of the new compounds were established by NMR spectroscopy and high-resolution electrospray ionization mass spectrometry, and the absolute configurations of enantiomers 1a and 1b were determined by electronic circular dichroism spectroscopy. All the new compounds exhibited antioxidant activities with IC50 values of 19.45–81.98 μM, as evaluated using free-radical scavenging assays, with the highest activity observed for compound 2. In addition, compounds 1a, 1b, and 2 exhibited inhibitory activities on intracellular reactive oxygen species generation.
Highlights
Mantidis ootheca, which refers to egg cases of the Mantidae family, such as Tenodera angustipennis Saussure, Hierodula patellifera Serville, Statilia maculate Thunberg, and Tenodera sinensis Saussure, has been used as a source of traditional medicines in East Asia, including Korea and China [1]
Dried T. angustipennis egg cases selected from a commercial Mantidis ootheca material were ground and extracted with 70% EtOH
Fifteen compounds were isolated from the extract and structural determination was performed (Figure 1)
Summary
Mantidis ootheca, which refers to egg cases of the Mantidae family, such as Tenodera angustipennis Saussure, Hierodula patellifera Serville, Statilia maculate Thunberg, and Tenodera sinensis Saussure, has been used as a source of traditional medicines in East Asia, including Korea and China [1]. Various pharmacological studies on Mantidis ootheca have been reported, only a few studies have investigated its chemical constituents. The chemical constituents of Mantidis ootheca have been revealed to include fatty acids and phenols that exhibit pharmacological properties, such as antibacterial, antibiofilm, antioxidant, and anti-atherosclerotic effects [7,8,9]. Previous studies have indicated that commercially available Mantidis ootheca products contain the egg cases of several mantis species within one package [10]. As such mixtures may be used for research, the exact identification of research samples is of particular importance
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