Abstract
Tagetespatula L. is a widely cultivated herbal medicinal plant in China and other countries. In this study, two new 2, 3-dihydrobenzofuran glucosides (1, 2) and fourteen known metabolites (3–16) were isolated from the stems and leaves of T. patula (SLT). The chemical structures of the isolated compounds were characterized comprehensively based on one- and two-dimensional NMR spectroscopy and high resolution mass spectrometry. Absolute configurations of compounds 1 and 2 were determined by ECD calculations. Compounds 1 and 2 exhibited moderate in vitro inhibitory activities against human gastric cancer cell lines (AGS) with IC50 values of 41.20 μmol/L and 30.43 μmol/L, respectively. The fingerprint profiles of stems and leaves of T. patula with three color types of flowers (Janie Yellow Bright, Jinmen Orange, Shouyao Red and Yellow color) were established by high-performance liquid chromatography (HPLC). Ten different batches of stems and leaves were examined as follow: Shouyao Red and Yellow color (1, 2, 3), Janie Yellow Bright (4, 5, 6, 7) and Jinmen Orange (8, 9, 10). Twenty-two common peaks were identified with similarity values ranging from 0.910 to 0.977. Meanwhile, the average peak area of SLT in the three types of flowers was different and it was the highest in Janie Yellow Bright.
Highlights
Tagetes genus belongs to the family Compositae (Asteraceae) and comprises about 55 different species including Tagetespatula Linn. (French marigold) which is an annual well-known ornamental and medicinal plant distributed worldwide [1]
We report the isolation and structural elucidation of two new euparin glycosides and 14 known compounds (Figure 1)
Compound 1 was obtained from the 95% EtOH extract of the T. patula L as a white amorphous powder
Summary
Tagetes genus belongs to the family Compositae (Asteraceae) and comprises about 55 different species including Tagetespatula Linn. (French marigold) which is an annual well-known ornamental and medicinal plant distributed worldwide [1]. (French marigold) which is an annual well-known ornamental and medicinal plant distributed worldwide [1]. In China, T. patula is a common ornamental and medicinal plant and has been cultivated throughout the country. The plant is specially used as an antimicrobial, antiseptic, blood purifying, and diuretic agent [3,4]. The flowers of T. patula are edible and used in refreshing drinks [5]. Previous phytochemical investigations of flowers of T. patula were mainly focused on the flavonoids [6,7], steroids [8], and thiophenes [9]. Its roots and rhizomes contained higher contents of thiophenes [10] and benzofurans [11]. We report the isolation and structural elucidation of two new euparin glycosides and 14 known compounds (Figure 1)
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