Abstract
Dactylicapnos torulosa (D. torulosa) has been traditionally used as a therapeutic remedy. Here, a combined strategy using both phytochemical and biological approaches was conducted to discern the effective components of D. torulosa . Three new alkaloids, namely, ( 1 – 3 ), Torulosine A, 1-Methoxypseudoprotopine and 1,14-Dimethoxyprechilenine together with 33 ( 4 – 36 ) known compounds were isolated. The structures of the new compounds were fully established by extensive analysis of HR-ESI-MS NMR and CD spectroscopic data. These compounds were then screened using zebrafish bioassay methods for antithrombotic activities. Compounds 5 and 7 had the best antithrombotic effect with prevention rates of 100% at 50 μM, and Compounds 8 , 4 , 9 and 11 at 50 μM had prevention rates of 81.3%, 79.4%, 84.4% and 79.3%, respectively. The antithrombotic effect of compounds may be related to their inhibitory effect on platelet aggregation. The present study contributes to the diverse chemical and bioactivity data of the Dactylicapnos genus. • Three new alkaloids ( 1 – 3 ) were isolated from Dactylicapnos torulosa. • Structural characterization data of 4 filled up a deficiency in the present literature. • Compounds 5 and 7 at 50 μM showed antithrombotic prevention rate of 100%.
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