Abstract
Two new 2H-pyran-2-one glucosides, cuscutarosides A (1) and B (2), and one new steroidal glucoside, 7β-methoxy-β-sitosterol 3-O-β-glucopyranoside (3), together with 12 known compounds (4–15) were isolated from the whole plant of Cuscuta reflexa (Convolvulaceae) collected from Myanmar. The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis. The antiobesity activity of these isolates was evaluated using porcine pancreatic lipase (PPL), and the antiplatelet aggregation activity was screened using rabbit platelets induced by thrombin, platelet-activating factor (PAF), arachidonate (AA), or collagen. 7β-Methoxy-β-sitosterol 3-O-β-glucopyranoside (3) showed weak PPL inhibitory activity. Cuscutaroside A (1), its acetylated derivative (1a), and scrophenoside B (8) showed weak inhibitory activity against rabbit platelet aggregation induced by collagen. Compound 1a also showed inhibitory activity against rabbit platelet aggregation induced by AA.Graphic
Highlights
2 Results and DiscussionCuscuta reflexa Roxb. (Convolvulaceae), a twining parasitic plant, is distributed in China, Afghanistan, India, Indonesia, Malaysia, Myanmar, Nepal, Pakistan, Sri Lanka, and Thailand [1]
We report the structural elucidation of three new compounds from the whole plant of C. reflexa and the results of a bioassay for the inhibitory activities against porcine pancreatic lipase (PPL) and rabbit platelet aggregation
Cuscutaroside A (1), 1a, and scrophenoside B (8) showed weak inhibitory activity against rabbit platelet aggregation induced by collagen with IC50 values of 291.4 ± 47.9 μg/mL, 63.8 ± 4.4 μg/mL, and 180.5 ± 6.7 μg/mL, respectively, compared with aspirin (IC50 = 33.3 ± 1.3 μg/mL)
Summary
Cuscuta reflexa Roxb. (Convolvulaceae), a twining parasitic plant, is distributed in China, Afghanistan, India, Indonesia, Malaysia, Myanmar, Nepal, Pakistan, Sri Lanka, and Thailand [1]. Named shwe-new or shwe-nwe-pin (Hsay) in Myanmar, the whole plant of C. reflexa is used to treat inflammation, irregularities of the blood, and other diseases [3]. It is medically used in India, Nepal, Bangladesh, and Pakistan [4]. The extract of C. reflexa was found to have in vitro thrombolytic activity [11] This finding may somewhat explain its traditional use in the treatment of irregularities of the blood. We report the structural elucidation of three new compounds from the whole plant of C. reflexa and the results of a bioassay for the inhibitory activities against PPL and rabbit platelet aggregation
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