Abstract
A new sterol, aspersterol E (1), a newly discovered alkaloid, asperginine A (2), and five known compounds (3–7) were obtained from the endophytic fungus Aspergillus sp. S3 of Hibiscus tiliaceus Linn. The compounds were extracted from their fermentation products using silica gel, ODS C18, and semi-preparative HPLC. The structure of each compound was determined through spectroscopic analysis. All the obtained compounds (1–7) were evaluated for their cytotoxic activity against the mouse pre-gastric cancer cell line MFC by using the MTT assay. The IC50 values of compounds 1, 2, 3, and 5 were found to be 153.43 μM, 61.25 μM, 73.19 μM, and 181.69 μM respectively.
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