Abstract
Sonneratia alba J.E. Smith, Sonneratiaceae widely grows in mangrove forests. There were some studies on plants of mangrove forests, and these results showed they contained many interesting bioactive compounds. Nevertheless, Sonneratia alba has not much been studied, especially, has not yet been chemically and biologically studied in Viet Nam. From the petroleum ether extract of the leaves of Sonnertia alba, oleanolic acid (1), betulin (2), betulinic acid (3), alphitolic acid (4), methyl gallate (5) and 5-hydroxymethylfurfural (6) were isolated. Their structures were identified by comparing their NMR data as well as the physical properties with those in literatures. Among them, (1) had high yield (about 0.15% of dried leave) with numerous pharmacological activities including inhibitory activity against HIV-1 protease with IC50 of 6.3 mM, anti-inflammatory, anti-cancer. So, Sonneratia alba should be exploited to afford to a valuable source in food and pharmaceutical products. Further studies on this plant are in progress.
Highlights
There were some studies on plants of mangrove forests, and these results showed plants of mangrove forests contained many interesting bioactive compounds such as triterpeneoids, steroids, glycosides, flavonoids, alkaloids, quinonoids
Oleanolic acid was known to have numerous of pharmacological activities including inhibitory activity against HIV-1 protease with IC50 of 6.3 μM [10], anti-inflammatory, anti-cancer, and hepato-protective effects, that were tested for their ability to modulate the activities of several cytochrome P450 (CYP) enzymes using human liver microsomes [4], inhibition the growth of ras oncogene-transformed R6 cells without toxicity to the normal cells [8]
(1) had high yield, about 0.15% of dried leaves, and this material is collected in mangrove forest
Summary
The isolation and structural determination of six compounds: oleanolic acid (1), betulin (2), betulinic acid (3), alphitolic
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
