Abstract
Chemical Constituents from Diospyros discolor Willd. and their Acetylcholinesterase Inhibitory Activity
Highlights
IntroductionD. discolor was reported to have free radical scavenging, anti-diarrheal, antimicrobial, analgesic and anti-inflammatory activities[1,2,3,4,5]
The triterpenes found in Diospyros sp. were mostly of pentacyclic core especially lupane, ursane and oleanane skeleton[6]
The compounds examined for AChE inhibitory activity showed moderate inhibiton concentration except for stigmast4-en-3-one (7)
Summary
D. discolor was reported to have free radical scavenging, anti-diarrheal, antimicrobial, analgesic and anti-inflammatory activities[1,2,3,4,5]. Diospyros discolor is commonly known as ‘buah mentega’ and traditionally used to treat various diseases. Many compounds especially triterpenes in Diospyros sp. Were reported to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase enzymes in vitro and in vivo. D. discolor was reported to contain triterpenes, yet to be investigated for their AChE inhibitory activity. AChE inhibitory activity at the concentration of 100 μg/mL. Objective: The aim of the present study is to identify chemical constituents from D. discolor and their AChE inhibitory activity
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